Prediction of Postmenopausal Status in Premenopausal Early Stage Breast Cancer Patients after Adjuvant Chemotherapy
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چکیده
The incidence of CIA associated with regimens involving cyclophosphamide or anthracyclines ranges from 53-89%. And the incidence of amenorrhea reported from the recently presented BCIRG-01 trial comparing TAC; (Docetaxel, Doxorubicin, and cyclophosphamide) and FAC; (5-FU, Doxorubicin, and Cyclophosphamide) in early-stage breast cancer was 32.8% in patients receiving FAC. However, this trial was presented at an early stage of follow-up, and the method of assessment was not reported [3,4].
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بررسی هیستوپاتولوژی و مارکرهای بیولوژی در زنان مبتلا به سرطان پستان قبل از یائسگی (زیر 40 سال) و پس از یائسگی (بالای 60 سال) در بیمارستان رسول اکرم(ص) و آتیه
Background & Aim: Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma death in women.One of the factors which have been proposed in prognosis and treatment of breast carcinoma is hormonal status and hormonal receptors. In this study, we investigated histopathology(prognostic factors) and biologic markers(estrogen receptor ER, progesterone receptor PR, P53...
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BACKGROUND To evaluate effects of neoadjuvant chemotherapy on the bone turnover markers of preoperational breast cancer patients. METHODS Forty-one breast cancer patients (29 premenopausal and 12 postmenopausal) and 60 healthy women (30 premenopausal and 30 postmenopausal) aged 30-64 years, were evaluated for their bone status. Serum levels of the bone formation markers PINP and BAP, as well ...
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UNLABELLED Adjuvant systemic therapy reduces the likelihood of both local and distant relapses by eradicating micrometastases. AIM To survey the adjuvant treatment of early breast cancer. METHODS Author presents an overview of the systemic therapy of early breast cancer based on relevant literature and own experiences. RESULTS Three systemic treatment modalities are widely used as adjuvan...
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BACKGROUND Understanding trends in the dissemination of findings from clinical research can help in estimating their population-level benefits. We evaluated trends in the use of adjuvant multi-agent chemotherapy, tamoxifen, and the combination of both treatments for early-stage breast cancer in the United States from 1975 through 1999. METHODS Data on treatment of 217 508 patients diagnosed f...
متن کاملImpact of chemotherapy-induced amenorrhea in breast cancer patients: the evaluation of ovarian function by menstrual history and hormonal levels
BACKGROUND Chemotherapy-induced amenorrhea (CIA) is one of the most frequent therapy-related adverse events observed in breast cancer patients who have undergone chemotherapy. Although the characteristics of CIA have been studied in Western countries, little is known about CIA in Asian. We conducted a retrospective analysis to assess the characteristics and influencing factors of CIA and its as...
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